https://alhikmah.edu.ng/ajpas/index.php/ajpas <p><strong>Instructions and guidelines to authors</strong></p> <p>Please read the instructions and guidelines carefully and adhere strictly to them to ensure efficient review process and publication of your paper.</p> <p><strong>Journal Policy</strong></p> <p>AJPAS will only publish research articles that have not been published or submitted to any other journal. Additionally, AJPAS will not publish any article that has already been reported fully or in parts or accepted for publication either in a journal or conference proceeding in any form, in print or electronic media. It is the sole responsibility of the author(s) at the point of submission to ensure that articles are new, original and have not been published in any form, fully or partly in any media. Such article to be submitted must not violate any or infringe upon copyrights of others and must not contain plagiarized or wrongfully attributed materials. Author(s) will be solely responsible for violation of this policy or ethics of academic publications.</p> <p><strong>Scope of the Journal</strong></p> <p>Al-Hikmah Journal of Pure and Applied Sciences (AJPAS) is dedicated to and covers all areas of fundamental and applied sciences including the followings:</p> <p>Physical Sciences – Chemistry, Industrial Chemistry and Physics</p> <p>Geological Sciences – Geology and Mineral Science</p> <p>Biological Sciences – Biochemistry, Microbiology, Zoology, Plant Biology and Botany</p> <p>Mathematical Sciences – Mathematics, History of Mathematics, Mathematics Education and Popularization of Mathematics, Computer Science and Statistics</p> <p>Environmental Science and relevant areas of Agricultural Science</p> Al-Hikmah Journal of Pure and Applied Science en-US AJPAS JOURNAL 2488-8834 https://alhikmah.edu.ng/ajpas/index.php/ajpas/article/view/46 <p>Malaria is one of the main causes of mortality and morbidity in the world, endangering billions and affecting millions of people each year. Resistance to common antimalarial drugs has proven to be a challenging problem in malaria control. In an attempt to develop efficacious compounds against sensitive and multidrug resistant falciparum malaria, four new complexes of mixed ligands (artemether and lumefantrine) were synthesized using template method. Their antiplasmodial activity potential was evaluated and compared with chloroquine and the parent ligands. The compounds were active against the tested parasite strains. The presence of the metal ions significantly improved the antiplasmodial action against the drug-resistant parasite strains when compared to chloroquine. Additionally, their biological activity was assessed using several in vitro assays. Biological and physical properties were correlated to the antimalarial activity.</p> ajpas ajpas ##submission.copyrightStatement## 2019-02-13 2019-02-13 6 30 36